Curious how cells are kept running like well-oiled machines, Vaishnavi Ananthanarayanan uses high resolution, live cell imaging to investigate cellular dynamics within the crowded environment inside mammalian cells.Ìý
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The Biro Group investigates how immune cells locate and kill cancer cells, adopting multi-disciplinary methods encompassing biophysics, cell biology, immunology, cancer biology, advanced microscopy, image analysis, and mathematical and coputational modelling.
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The Davis Lab explores how intracellular calcium signalling orchestrates the development, function and regeneration of the mammary gland. Our research utilizes genetic model organisms and quantitative imaging (across the scales of cells, tissues and the organ as a whole).
The Faridani lab uses state-of-the-art technology in the field of "single cell omics" to tackle hard-to-crack problems of cancer treatment, with a focus on pancreatic cancer and other solid tumours. The main goal of the lab is to tailor treatment for each patient.
The CTRU studies the building blocks of cell architecture and develops therapeutic strategies based on drug-targeting these building blocks. Our focus is the actin cytoskeleton that is responsible for the internal scaffolds of cells, the generation and reaction to force exerted by the environment and the movement of cells throughout the body.Ìý
Our laboratory utilises a variety of in vitro, ex vivo and in vivo techniques to dissect out the role of key transporters and metabolic enzymes in cancer growth. We have determined a number of metabolic pathways that are differentially regulated in breast cancer, prostate cancer, melanoma and more recently glioblastoma.
The critical role of the tumour microenvironment in cancer growth and survival suggests it is vulnerable to intervention.ÌýWe aim to improve the survival rate of cancer patients by deciphering and therapeutically exploiting elements of the tumour microenvironment that facilitate chemoresistance.
The Cancer Systems Microscopy Lab aims to contribute to improved cancer treatment outcomes by advancing: Precision Diagnostics;ÌýTargeted Therapies; and Fundamental Insights.
Our research group is at the intersection of systems immunology and artificial intelligence (AI). Our vision is to develop cutting-edge knowledge and tools to unravel the intricate workings of T cells and harness their potential in modern immunotherapy.
Our team is dedicated to improving treatments for patients with pancreatic cancer. We have developed a patient-centered drug development pipeline focusing on the unmet clinical challenges faced by patients which include, the heterogeneity of tumours, the scar tissue fortress, and tumour metastasis.
We are a molecular and cell biology laboratory with a research focus in blood development and leukemia. Our research interest lies in identifying critical components of the hematopoietic transcriptional network in healthy and leukemic blood stem cells and how these govern stemness.Ìý
The Poole group are interested in how cells can "feel" their surroundings. Our research seeks to identify how cells sense and respond to changing mechanical inputs by identifying the molecules that can convert forces into electrical or biochemical signals that influence cell behaviour.Ìý
Despite an overall improvement in survival in children with cancer, survival rates for those with aggressive cancers, such as high-risk neuroblastoma and brain tumours, remain dismal. Moreover, survivors frequently have life-long health issues due to the toxic effects of chemotherapy. Targeted and less toxic therapies are urgently required.
Our lab studies the molecular and metabolic mechanisms that underlie biological ageing, with a focus on its impacts on female fertility. A key mechanistic interest for the lab is the role of altered metabolism, including the molecular metabolism of the redox cofactor nicotinamide adenine dinucleotide (NAD+).
The Centre for Molecular Oncology applies basic, translational and clinical approaches to understanding cancer biology through patient-centred discovery programs, and uses this information to improve patient outcomes through clinical trials.Ìý
Biophysics
Curious how cells are kept running like well-oiled machines, Vaishnavi Ananthanarayanan uses high resolution, live cell imaging to investigate cellular dynamics within the crowded environment inside mammalian cells.Ìý
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The Biro Group investigates how immune cells locate and kill cancer cells, adopting multi-disciplinary methods encompassing biophysics, cell biology, immunology, cancer biology, advanced microscopy, image analysis, and mathematical and coputational modelling.
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To combat viruses, host cells have developed weapons to sabotage the delivery of viral genetic code into their nuclei. There are specialised proteins that either prematurely crack open the protective viral capsid encasing the virus—exposing its genetic material to degradation—or lock the DNA in so it cannot enter the nucleus.
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The Davis Lab explores how intracellular calcium signalling orchestrates the development, function and regeneration of the mammary gland. Our research utilizes genetic model organisms and quantitative imaging (across the scales of cells, tissues and the organ as a whole).
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Jesse Goyette wants to understand exactly how T cells transmit signals to initiate an immune response. How does the T cell receptor work? What does a T cell need to be activated?
Broadly, our aim is to translate discoveries about transmembrane receptor and ion channel signal transduction, into new platforms for treatment of neurological disorders. Our research program focuses on neuroprotection and repair in sensori-motor pathways.
David Jacques is teasing apart the molecular interactions between viral and host proteins to figure out how viruses like HIV and HTLV trick the host into enabling infection while simultaneously escaping cellular defense networks.
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Electrical and chemical signals generated within cells, tissues and organ systems drive vital functions. Izzy Jayasinghe and her team investigate how these signals are relayed to trigger a heartbeat, and drive other bodily functions, by combing super-resolution microscopy tools they develop with existing technologies.
The critical role of the tumour microenvironment in cancer growth and survival suggests it is vulnerable to intervention.ÌýWe aim to improve the survival rate of cancer patients by deciphering and therapeutically exploiting elements of the tumour microenvironment that facilitate chemoresistance.
The Cancer Systems Microscopy Lab aims to contribute to improved cancer treatment outcomes by advancing: Precision Diagnostics;ÌýTargeted Therapies; and Fundamental Insights.
Our research is focused on investigating how different viruses interact with and overcome the complex membranous system that surround and reside within the cell.Ìý
The Poole group are interested in how cells can "feel" their surroundings. Our research seeks to identify how cells sense and respond to changing mechanical inputs by identifying the molecules that can convert forces into electrical or biochemical signals that influence cell behaviour.Ìý
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Emma Sierecki–together with Yann Gambin–is mapping protein interactions to solve mysteries that have so far eluded researchers. Their strategy–combining cell-free protein expression with AlphaScreen and single molecule fluorescence spectroscopy–allows them to rapidly screen a huge number of protein binding partners.
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Yann Gambin is watching how certain proteins clump together, leading to cell death and Parkinson’s disease. Together with Emma Sierecki, he is using single-molecule approaches–to watch proteins working with each other–that are ten times faster than traditional approaches.
Since the establishment of the Baum lab at UNSW in 2022, the group has been passionately committed to translational research to accelerate the reduction in the global disease burden caused by Malaria.ÌýÌý
The Biro Group investigates how immune cells locate and kill cancer cells, adopting multi-disciplinary methods encompassing biophysics, cell biology, immunology, cancer biology, advanced microscopy, image analysis, and mathematical and coputational modelling.
opens in a new window
To combat viruses, host cells have developed weapons to sabotage the delivery of viral genetic code into their nuclei. There are specialised proteins that either prematurely crack open the protective viral capsid encasing the virus—exposing its genetic material to degradation—or lock the DNA in so it cannot enter the nucleus.
The Viral Immunity Group is focused on understanding the host-pathogen interaction of human RNA viruses (hepatitis C, norovirus, dengue, influenza, SARS CoV-2). We have made several seminal discoveries in the topics of virus transmission and characterisation of protective immune responses against RNA viral infections.Ìý
The group is interested in diseases that develop in the anterior segment of the eye including those that arise on the surface of the cornea because of deficiency in stem cells, environmental insults, from infection or autoimmunity.Ìý
Jesse Goyette wants to understand exactly how T cells transmit signals to initiate an immune response. How does the T cell receptor work? What does a T cell need to be activated?
The CTRU studies the building blocks of cell architecture and develops therapeutic strategies based on drug-targeting these building blocks. Our focus is the actin cytoskeleton that is responsible for the internal scaffolds of cells, the generation and reaction to force exerted by the environment and the movement of cells throughout the body.Ìý
The focus of research in this group is the inflammatory mediators that drive inflammation in lung diseases including asthma, chronic obstructive pulmonary disease (COPD) and sarcoidosis.Ìý
David Jacques is teasing apart the molecular interactions between viral and host proteins to figure out how viruses like HIV and HTLV trick the host into enabling infection while simultaneously escaping cellular defense networks.
The goal of our team is to identify microbial and host components contributing to treatment response, allowing the development and transition to defined microbial therapies.Ìý
Our research group is at the intersection of systems immunology and artificial intelligence (AI). Our vision is to develop cutting-edge knowledge and tools to unravel the intricate workings of T cells and harness their potential in modern immunotherapy.
Our research focuses on uncovering causes and developing treatments for gut and bladder diseases. For gut research, we study diseases like ulcerative colitis and Crohn’s disease using human specimens, supported by a unique tissue bank from colorectal surgery collaborations.Ìý
Our research is focused on investigating how different viruses interact with and overcome the complex membranous system that surround and reside within the cell.Ìý
Emma Sierecki–together with Yann Gambin–is mapping protein interactions to solve mysteries that have so far eluded researchers. Their strategy–combining cell-free protein expression with AlphaScreen and single molecule fluorescence spectroscopy–allows them to rapidly screen a huge number of protein binding partners.
opens in a new window
Yann Gambin is watching how certain proteins clump together, leading to cell death and Parkinson’s disease. Together with Emma Sierecki, he is using single-molecule approaches–to watch proteins working with each other–that are ten times faster than traditional approaches.
Our research program to define functional biology of a family of immune regulatory molecules, known as Leukocyte Immunoglobulin-like Receptors (LILRs) in innate immune responses, chronic inflammatory diseases and central nervous system injuries.Ìý
Despite an overall improvement in survival in children with cancer, survival rates for those with aggressive cancers, such as high-risk neuroblastoma and brain tumours, remain dismal. Moreover, survivors frequently have life-long health issues due to the toxic effects of chemotherapy. Targeted and less toxic therapies are urgently required.
Our lab studies the molecular and metabolic mechanisms that underlie biological ageing, with a focus on its impacts on female fertility. A key mechanistic interest for the lab is the role of altered metabolism, including the molecular metabolism of the redox cofactor nicotinamide adenine dinucleotide (NAD+).
Neuroscience
Curious how cells are kept running like well-oiled machines, Vaishnavi Ananthanarayanan uses high resolution, live cell imaging to investigate cellular dynamics within the crowded environment inside mammalian cells.Ìý
The research conducted in the Brain, Blood Pressure and Stress laboratory aims to understand how the brain controls the autonomic and cardiovascular changes associated with stress, emotions and hyperarousal.
The CNS Gene Therapy Group is interested in the molecular mechanisms of normal and pathological functions of neurons and myelin-forming cells in the central nervous system. Our main focus is on a group of neurological disorders termed leukodystrophies.Ìý
The CTRU studies the building blocks of cell architecture and develops therapeutic strategies based on drug-targeting these building blocks. Our focus is the actin cytoskeleton that is responsible for the internal scaffolds of cells, the generation and reaction to force exerted by the environment and the movement of cells throughout the body.Ìý
Broadly, our aim is to translate discoveries about transmembrane receptor and ion channel signal transduction, into new platforms for treatment of neurological disorders. Our research program focuses on neuroprotection and repair in sensori-motor pathways.
Our lab investigates cellular and physiological mechanisms used by autonomic systems; cardiovascular, respiratory and glucoregulatory. Physiological reflexes (e.g. baroreflex, chemoreflex, glucose counter regulation) function to maintain homeostasis in the healthy state.
The principal aim of our research is to understand the relationship between the nervous system and the immune system, with particular emphasis on how immune cells and their mediators affect chronic pain conditions, such as neuropathic pain, and to assess immunotherapeutic approaches.Ìý
Our research addresses critical questions concerning how provision of a varied, energy rich diet can override the control mechanisms that otherwise maintain body weight, with a particular focus on the brain-gut axis and cognitive decline, using rodent models.ÌýÌý
Our group examines how changes in neurons and their connections mediate learning. We focus on motivated learning which underlies addiction and associated behaviours. This work complements Psychology collaborators who investigate the behavioural effects of manipulating these circuits.
Emma Sierecki–together with Yann Gambin–is mapping protein interactions to solve mysteries that have so far eluded researchers. Their strategy–combining cell-free protein expression with AlphaScreen and single molecule fluorescence spectroscopy–allows them to rapidly screen a huge number of protein binding partners.
opens in a new window
Yann Gambin is watching how certain proteins clump together, leading to cell death and Parkinson’s disease. Together with Emma Sierecki, he is using single-molecule approaches–to watch proteins working with each other–that are ten times faster than traditional approaches.
As humans, we use touch to feel, to communicate, to move, to explore the environment around us, and to protect us from danger. What may seem like instinctive reactions are in fact the result of a complex interplay between our brain, nerves and touch receptors in our skin.
The CTRU studies the building blocks of cell architecture and develops therapeutic strategies based on drug-targeting these building blocks. Our focus is the actin cytoskeleton that is responsible for the internal scaffolds of cells, the generation and reaction to force exerted by the environment and the movement of cells throughout the body.Ìý
Broadly, our aim is to translate discoveries about transmembrane receptor and ion channel signal transduction, into new platforms for treatment of neurological disorders. Our research program focuses on neuroprotection and repair in sensori-motor pathways.
Our research focuses on uncovering causes and developing treatments for gut and bladder diseases. For gut research, we study diseases like ulcerative colitis and Crohn’s disease using human specimens, supported by a unique tissue bank from colorectal surgery collaborations.Ìý
The Cancer Systems Microscopy Lab aims to contribute to improved cancer treatment outcomes by advancing: Precision Diagnostics;ÌýTargeted Therapies; and Fundamental Insights.
Our team is dedicated to improving treatments for patients with pancreatic cancer. We have developed a patient-centered drug development pipeline focusing on the unmet clinical challenges faced by patients which include, the heterogeneity of tumours, the scar tissue fortress, and tumour metastasis.
The Cardiovascular and Metabolic Disease Research Group is co-led by Prof. Kerry-Anne Rye, opens in a new window and A/Prof. Shane Thomas. The research group consists of post-doctoral scientists, PhD students and honours students.Ìý
The specific focus of the Orphan Receptor Laboratory is the discovery of new drugs for receptors where the partner hormone is still to be found. These are called ‘orphan’ G protein-coupled receptors and make up the majority of all receptors in the family.Ìý
Despite an overall improvement in survival in children with cancer, survival rates for those with aggressive cancers, such as high-risk neuroblastoma and brain tumours, remain dismal. Moreover, survivors frequently have life-long health issues due to the toxic effects of chemotherapy. Targeted and less toxic therapies are urgently required.
My team has developed an Australian national biobank of stem-cell-derived airway and gut organoids, and has built a platform for high-throughput functional therapy-testing on patients organoids.
Our lab studies the molecular and metabolic mechanisms that underlie biological ageing, with a focus on its impacts on female fertility. A key mechanistic interest for the lab is the role of altered metabolism, including the molecular metabolism of the redox cofactor nicotinamide adenine dinucleotide (NAD+).
The CTRU studies the building blocks of cell architecture and develops therapeutic strategies based on drug-targeting these building blocks. Our focus is the actin cytoskeleton that is responsible for the internal scaffolds of cells, the generation and reaction to force exerted by the environment and the movement of cells throughout the body.Ìý
Electrical and chemical signals generated within cells, tissues and organ systems drive vital functions. Izzy Jayasinghe and her team investigate how these signals are relayed to trigger a heartbeat, and drive other bodily functions, by combing super-resolution microscopy tools they develop with existing technologies.
Our lab investigates cellular and physiological mechanisms used by autonomic systems; cardiovascular, respiratory and glucoregulatory. Physiological reflexes (e.g. baroreflex, chemoreflex, glucose counter regulation) function to maintain homeostasis in the healthy state.
Our research addresses critical questions concerning how provision of a varied, energy rich diet can override the control mechanisms that otherwise maintain body weight, with a particular focus on the brain-gut axis and cognitive decline, using rodent models.ÌýÌý
The Cardiovascular and Metabolic Disease Research Group is co-led by Prof. Kerry-Anne Rye, opens in a new window and A/Prof. Shane Thomas. The research group consists of post-doctoral scientists, PhD students and honours students.Ìý
Our research focusses on the use of novel digital technologies to enhance student engagement, motivation and success. This includes the development and evaluation of interactive online modules, digital tools for learning and assessment and immersive virtual environments.
