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Dr Jingjing Li

Dr Jingjing Li

Postdoctoral Fellow

Doctor of Philosophy (Biomedical Engineering) (2015Ìý– 2019),ÌýUniversity of New South Wales, Sydney, Australia

Master of Biomedical Engineering (by research) (2009-2011),ÌýUniversity of New South Wales, Sydney, Australia

Bachelor of Biomedical Engineering (2003 – 2007),ÌýCapital Medical University, Beijing, China

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Engineering
Grad Sch: Biomedical Eng

Dr Jingjing Li is aÌý Postdoctoral Fellow at the Graduate School of Biomedical Engineering. She is working with on ARC Linkage and CRC-P project developing an automated microscale bioreactor for cell and gene therapy. Her research is at the interface of biology and engineering, focusing on the development of microfluidic organ on chip systems and their application in stem cell science, cardiovascular and blood development.Ìý

Being trained as a biomedical engineer, she developed multidiscipline skills spans from microfluidics, stem cell biology, and bioinformatics. Her PhD and Post-Doctoral research focus on studying the influence of pulsatile fluid shear stress on human embryonic blood formation using microfluidic model mimicking foetal circulation, live cell imaging of Ìýand single-cell RNA sequencing of developing blood niches. She is now working on upscaling theÌýmicrofluidic organ-on-a-chip models and applying them in the expansion, maturation and engraftment of blood stem and progenitor cells.
E-mail
jingjing.li@unsw.edu.au
Location
Samuels 514, F25 UNSW Sydney Kensington 2052
  • Journal articles | 2024
    Belbachir S; Abraham A; Sharma A; Prockop S; DeZern AE; Bonfim C; Bidgoli A; Li J; Ruggeri A; Bertaina A; Boelens JJ; Purtill D, 2024, 'Engineering the best transplant outcome for high-risk acute myeloid leukemia: the donor, the graft and beyond', Cytotherapy, 26, pp. 546 - 555,
    Journal articles | 2024
    Gupta AO; Azul M; Bhoopalan SV; Abraham A; Bertaina A; Bidgoli A; Bonfim C; DeZern A; Li J; Louis CU; Purtill D; Ruggeri A; Boelens JJ; Prockop S; Sharma A, 2024, 'International Society for Cell & Gene Therapy Stem Cell Engineering Committee report on the current state of hematopoietic stem and progenitor cell–based genomic therapies and the challenges faced', Cytotherapy,
    Journal articles | 2024
    John TD; Maron G; Abraham A; Bertaina A; Bhoopalan SV; Bidgoli A; Bonfim C; Coleman Z; DeZern A; Li J; Louis C; Oved J; Pavel-Dinu M; Purtill D; Ruggeri A; Russell A; Wynn R; Boelens JJ; Prockop S; Sharma A, 2024, 'Strategic infection prevention after genetically modified hematopoietic stem cell therapies: recommendations from the International Society for Cell & Gene Therapy Stem Cell Engineering Committee', Cytotherapy, 26, pp. 660 - 671,
    Journal articles | 2024
    Yu Z; Chen Y; Li J; Chen C; Lu H; Chen S; Zhang T; Guo T; Zhu Y; Jin J; Yan S; Chen H, 2024, 'A tempo-spatial controllable microfluidic shear-stress generator for in-vitro mimicking of the thrombus', Journal of Nanobiotechnology, 22,
    Journal articles | 2023
    Li J; Malouf C; Miles LA; Willis MB; Pietras EM; King KY, 2023, 'Chronic inflammation can transform the fate of normal and mutant hematopoietic stem cells', Experimental Hematology, 127, pp. 8 - 13,
    Journal articles | 2022
    Li J; Lao O; Bruveris FF; Wang L; Chaudry K; Yang Z; Farbehi N; Ng ES; Stanley EG; Harvey RP; Elefanty AG; Nordon RE, 2022, 'Mimicry of embryonic circulation enhances the hoxa hemogenic niche and human blood development', Cell Reports, 40,
    Journal articles | 2021
    Li J; Lao O; Nordon RE, 2021, 'The method to generate pulsatile circulatory fluid flow using microfluidics', MethodsX, 8,
    Journal articles | 2020
    Cornwell JA; Li J; Mahadevan S; Draper JS; Joun GL; Zoellner H; Asli NS; Harvey RP; Nordon RE, 2020, 'TrackPad: Software for semi-automated single-cell tracking and lineage annotation', SoftwareX, 11,
    Journal articles | 2020
    Wang L; Li J; Coad BR; McFarland CD; Nordon RE, 2020, 'Interaction of endothelial cells with plasma-polymer modified surfaces', Materialia, 9,
    Journal articles | 2019
    Chen H; Yu Z; Bai S; Lu H; Xu D; Chen C; Liu D; Zhu Y, 2019, 'Microfluidic models of physiological or pathological flow shear stress for cell biology, disease modeling and drug development', TrAC - Trends in Analytical Chemistry, 117, pp. 186 - 199,
    Journal articles | 2017
    Breadmore M, 2017, '7th Advances in Microfluidics & Nanofluidics (AMN)/9th International Symposium on Microchemistry and Microsystems (ISMM)/5th Asia-Pacific Chemical and Biological Microfluidic Conference (APCBM)/8th Australia New Zealand Nano-Microfluidics Symposium (ANZNMF) (Hobart, Australia, June 26–29, 2017)', Green Processing and Synthesis, 6, pp. 127 - 129,
    Journal articles | 2015
    Tay HL; Kaiko GE; Plank M; Li J; Maltby S; Essilfie A-T; Jarnicki A; Yang M; Mattes J; Hansbro PM; Foster PS, 2015, 'Antagonism of miR-328 increases the antimicrobial function of macrophages and neutrophils and rapid clearance of non-typeable Haemophilus influenzae (NTHi) from infected lung.', PLoS Pathog, 11, pp. e1004549,
    Journal articles | 2015
    Tay HL; Kaiko GE; Plank M; Li J; Maltby S; Essilfie A-T; Jarnicki A; Yang M; Mattes J; Hansbro PM; Foster PS, 2015, 'Correction: Antagonism of miR-328 Increases the Antimicrobial Function of Macrophages and Neutrophils and Rapid Clearance of Non-typeable Haemophilus Influenzae (NTHi) from Infected Lung.', PLoS Pathog, 11, pp. e1004956,
    Journal articles | 2013
    Cornwell J; Zhang H; Lim T; Resurreccion R; Port T; Rosengarten G; Nordon R; chen H, 2013, 'Cardiac-like flow generator for long-term imaging of endothelial cell responses to circulatory pulsatile flow at microscale', Lab on a chip : miniaturisation for chemistry, biology and bioengineering, 13, pp. 2999 - 3007,
    Journal articles | 2013
    Foster PS; Plank M; Collison A; Tay HL; Kaiko GE; Li J; Johnston SL; Hansbro PM; Kumar RK; Yang M; Mattes J, 2013, 'The emerging role of microRNAs in regulating immune and inflammatory responses in the lung', Immunological Reviews, 253, pp. 198 - 215,
    Journal articles | 2011
    Chen H; Li J; Zhang H; Li M; Rosengarten G; Nordon RE, 2011, 'Microwell perfusion array for high-throughput, long-term imaging of clonal growth', Biomicrofluidics, 5, pp. Article number: 044117,
    Journal articles | 2010
    Li JY; Yu ABOYAOYA-B; Bridgwater J; Rought S, 2010, 'Spontaneous inter-particle percolation: a kinematic simulation study', Powder Technology, 203, pp. 397 - 403
  • Conference Abstracts | 2022
    Ziaee F; Du E; Li J; Rnjak-Kovacina J; Thordarson P; Nordon R, 2022, 'DEVELOPING FULLY DEFINED SELF-ASSEMBLY PEPTIDE HYDROGELS FOR HUMAN PLURIPOTENT STEM CELL CULTURE', in TISSUE ENGINEERING PART A, MARY ANN LIEBERT, INC, Vol. 28, pp. S537 - S537,
    Conference Abstracts | 2019
    Li J; Bruveris F; Ed S; Elefanty A; Lao O; Ng E; Nordon R; Ralph P, 2019, 'THE ROLE OF SHEAR STRESS IN THE GENERATION OF DEFINITIVE HAEMATOPOIETIC LINEAGES AND ARTERIAL VASCULATURE FROM HUMAN PLURIPOTENT STEM CELLS AT THE SINGLE-CELL LEVEL', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, Vol. 76, pp. S73 - S74,
    Conference Abstracts | 2013
    Nordon RE; Cornwell J; Li J; Harvey RP; Schroeder T, 2013, 'Mapping and modelling ex vivo cell culture processes directly from cell tracking data', in Cytotherapy,
    Conference Papers | 2013
    Radford J; Wang L; Li J; McFarland C; Nordon RE, 2013, 'A Novel Flash Detection Algorithm for Single Molecule Counting with TIRF Microscopy', in From Nano to Macro, San Francisco, CA, USA, presented at International Symposium on Biomedical Imaging: From Nano to Macro, San Francisco, CA, USA, 07 April 2013 - 11 April 2013
    Conference Papers | 2010
    Ostrovski O; Zhang G; Kononov R; Dewan MA; Li J, 2010, 'Carbothermal Solid State Reduction of Stable Metal Oxides', Stockholm, Sweden, presented at Prof. S Seetharaman Symposium, Stockholm, Sweden, 14 June 2010 - 15 June 2010

CIA,ÌýEarly Career Researcher Seed Grant ,UNSW Engineering Faculty (2021)

CIA,ÌýInternational Seed Grant, UNSW Engineering Faculty (2022)

Contributor forÌýÌý

Scaling microfluidics for cell manufacture. Australian Research Council Linkage Grant LP160100570 (2016-2019)

Manufacturing 3D microstructures for the medical device industry. Australian Research Council Linkage Grant LP160100573 (2016-2019)

Travel Grants

2022Ìý Ìý Ìý The Australasian Society for Stem Cell Research (ASSCR) and the Australasian Gene and Cell Therapy Society (AGCTS) Joint Scientific Meeting / National Stem Cell Foundation of Australia (NSCFA) Travel AwardÌý

2019Ìý Ìý Ìý The Australasian Society for Stem Cell Research (ASSCR) and the Australasian Gene and Cell Therapy Society (AGCTS) Joint Scientific Meeting / National Stem Cell Foundation of Australia (NSCFA) Travel AwardÌý Ìý Ìý Ìý Ìý ÌýÌý

2019Ìý Ìý ÌýInternational Society of Experimental Hematology Conference AwardÌý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý

2018Ìý Ìý ÌýInternational Society of Stem Cell Research ECR and student Conference AwardÌý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý

2017Ìý Ìý ÌýAustralian Society for Stem Cell Research ECR and student Conference AwardÌý Ìý

2015-2017Ìý ÌýStem Cell Australia (SCA) Meeting Travel Grant

2010Ìý ÌýAustralian Society for Stem Cell Research (ASSCR) Conference Travel AwardÌý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý

Scholarship, Awards and Fellowship:

2019Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Best Poster Presentation Award, UNSW Cross Faculty Research SymposiumÌý Ìý Ìý Ìý Ìý Ìý

2018-2019Ìý Ìý Ìý Ìý ÌýPostdoctoral Writing FellowÌýAward, UNSW

2015-2019Ìý Ìý Ìý Ìý Women in Engineering Award, UNSWÌý

2015-2019Ìý Ìý Ìý Ìý ÌýFaculty Top-up Scholarship, UNSW, Engineering

2015-2019Ìý Ìý Ìý Ìý ÌýAustralia Postgraduate AwardÌý Ìý Ìý Ìý Ìý Ìý Ìý

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1. Modelling human heart, vascular and blood development from pluripotent stem cells on a microfluidic chip

We have used lab-on-chip to mimicÌýÌýand to model human blood formation from cells that line blood vessels. We are currently studying the influence of pulsatile blood flow and circulation on the generation of precursor blood stem cells. We are also investigating the use of hydrogels to pattern embryonic development of the cardiovascular system.

2. Enhancing the development of aortic vasculature and blood stem cell from pluripotent stem cells using dynamic culture system

We use upscaled Microfluidic circulation system and orbital shearing culture system to enhance the development of precursor blood stem cells. This work has been featured in Ìýand .

3. Stem cell engineering: the modification of human CD34+ blood stem and progenitor cells.

CD34+ blood stem and progenitor cells derived from sources such as cord blood, bone marrow, mobilised peripheral blood, and human pluripotent stem cells can be manipulated through various techniques of separation, stimulation and genetic modification. These modifications target the genetic or physical traits of the cells with the goal of improving their functionality, therapeutic potential, and compatibility for diverse applications in haematopoietic stem cell gene therapy (HSCGT) & immunotherapy.

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Research Society and Committee

International Society of Stem Cell Research (ISSCR)

International Society of Experimental Hematology (ISEH) -

International Society of Cell Therapy (ISCT)Ìý(Committee Spotlight)

UNSW Cardiac, Vascular & Metabolic Medicine Theme (CVMM) - Early Career Researcher Committee Member

IEEE Medical Imaging and Image processing

IEEE Engineering in Medicine & Biology Society (EMBS)

Australia Society of Stem Cell Research (ASSCR)

Engineers Australia

NSW Stem Cell Network

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Professional Society

Academic Representative, Level 3 WHS committee, Graduate School of Biomedical Engineering, UNSW

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My Research Supervision

Co-supervising PhD Candidate:

Ada Lee,ÌýLab-on-a-chip scale-out of autologous cell and gene therapies.

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My Teaching

BIOM9640 Biomedical Instrumentation

BIOM1010 Engineering in Medicine and Biology