Ӱ̳
Back to
Professor Hongyuan (Robert) Yang

Professor Hongyuan (Robert) Yang

Adjunct Professor
Science
School of Biotech & Biomolecular Science

Education

  • Bachelor of Medicine (1993), Peking University Health Science Centre, Beijing, China
  • PhD (1998), Columbia University, New York, USA

Professional Experience

  • 2022-: NHMRC Investigator L3
  • 2014-2019: NHMRC Senior Research Fellow B
  • 2013-current: Professor, School of BABS
  • 2010-2013: Inaugural ARC Future Fellow
  • 2009-2012: Associate Professor, School of BABS
  • 2007-2008: Senior Lecturer, School of BABS, UNSW
  • 1999-2007: Lecturer/Assistant Professor/Associate Professor with tenure, Department of Biochemistry, National University of Singapore
  • 1999 (April-July): Visiting Fellow, Harvard University
  • this article on Rob's career by The Journal of Cell Biology

Research Program and Contribution

Our long-term research interests focus on two fundamental yet emerging areas in cell and medical biology:

1. Intracellular lipid (e.g., cholesterol and phosphatidylserine) sorting/transport, and its role in cancer, heart and neurodegenerative diseases.
2. The biogenesis and dynamics of lipid droplets, adipocyte development, obesity and diabetes.

These two areas are closely linked because lipid droplets may play a crucial role in cellular lipidtransport, and lipid droplets are a primary storage site for both free and esterified cholesterol.

Cellular lipidtrafficking is a difficult subject to study given the lack of effective approaches to label lipids in live cells. However, it is an important cell biological question because lipids are actively sorted and transported in all eukaryotic cells. In addition, many human diseases such as atherosclerosis, Alzheimer’s and cancerare linked to aberrant lipidtransport.

My early work led to the identification of two key enzymes that catalyze sterol esterification, an important homeostatic step for storing excess sterols (Yang et al., Science, 1996). Our laboratory subsequently identified novel molecules and schemes that govern cellular lipidtransport (Wang et al., EMBO J, 2005; Du et al, J Cell Biol., 2011;Ghai et al, Nature Communications, 2017; Dong et al., Nat Comms, 2019; Wang et al., Molecular Cell, 2019;Du et al., JCB, 2020; Qian et al., Cell, 2020). Currently we aim to identify and characterize novel proteins that regulate the trafficking of cholesterol or phosphatidylserine between cellular organelles.

Lipid droplets are key cellular organelles that regulate energy storage and metabolism. We have identified a number of factors that impact the size of lipid droplets (Fei et al, J Cell Biol., 2008;Fei et al, PLoS Genetics, 2011). One such protein, seipin, also plays an important role in human adipocyte development and maintenance (Cui et al., Human Mol Gen., 2011; Liu et al, Diabetes, 2014; Pagac et al, Cell Reports, 2016; Yan et al, Developmental Cell, 2018). Currently, we aim to understand how lipid droplets are formed from the ER and the exact role of seipin in this process.

Honours and Awards

  • NHMRC Investigator L3 (2022-2027)
  • UNSW Dean of Science Research Excellence Award (2019)
  • NHMRC Senior Research Fellowship B (2014-2019)
  • Inaugural ARC Future Fellowship (2010-2014)
  • Yong Loo Lin School of Medicine Research Excellence Young Scientist Award (2006)
  • Finalist, Singapore National Young Scientist Award (2005)
  • National University of Singapore (NUS) Technopreneurship 21 Award (2004)
  • National University of Singapore (NUS) Young Scientist Award (2002)

Editorial Service

  • Member ofEditorial Board/Academic Editor, Journal of Cell Biology
  • Member ofEditorial Board, BBA-Molecular Cell Biology of Lipids

Selected Publications

Liu Y. andYang H. (2024) WIPI4 loss linked to ferroptosis.Nature Cell Biol., 26: 506-507

Li YE, Norris DM, Xiao FN, Pandzic E, Whan RM, Fok S, Zhou M, Du G, Liu Y, Du X,Yang H. (2024) Phosphatidylserine regulates plasma membrane repair through tetraspanin-enriched macrodomains.J Cell Biol; 223: e202307041.

Zadoorian A, DuX and Yang H. (2023)Lipid droplet biogenesis and functions in health and disease.Nature Reviews Endocrinology.https://doi.org/10.1038/s41574-023-00845-0

Lukmantara I, Chen F, Mak HY, Zadoorian A, Du X, Xiao FN, Norris DM, Pandzic E, Whan R, Zhong Q and Yang H. (2022) PI(3)P and DFCP1 regulate the biogenesis of lipid droplets. Mol Biol Cell. 33(14):ar131.

Mak HY, Ouyang Q, Tumanov S, Xu J, Rong P, Dong F, Lam SM, Wang X, Lukmantara I, Du X, Gao M, Brown AJ, Gong X, Shui G, Stocker R, Huang X, Chen S andYang H. (2021)AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway.Nature Communications. 12(1):6877. doi: 10.1038/s41467-021-27279-4.

Li YE, Wang Y, Du X, Zhang T, Mak HY, Hancock SE, McEwen H, Pandzic E, Whan RM, Aw YC, Lukmantara IE, Yuan Y, Dong X, Don A, Turner N, Qi S andYang H. (2021)TMEM41B and VMP1 are scramblases and regulate the distribution of cholesterol and phosphatidylserine.Journal of Cell Biology; 220 (6),e202103105. Highlighted by Faculty Opinionshttps://facultyopinions.com/prime/740025624#tab=recommendations

Yan R., Cao P., Song W., Qian H., Du X., Coates H.W., Zhao X., Li Y., Gao S., Gong X., Liu X., Sui J., Lei J., Yang H., Brown A.J., Zhou Q., Yan C. and Yan N. (2021) A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols. SCIENCE, 371(6533):eabb2224.doi:10.1126/science.abb2224.

Du X. and Yang H. (2021) Seipin regulates the formation of nuclear lipid droplets from a distance. Journal of Cell Biology; 220 (1): e202011166.

Qian H., Wu X., Du X., Yao X., Zhao X., Lee J., Yang H*, and Yan N*. (2020) Structural basis of low pH-dependent lysosomal cholesterol egress by NPC1 and NPC2. CELL, 182: 1-14. * Co-corresponding authors.

Gao M., Liu L., Wang X., Mak H.Y., Liu G. and Yang H. (2020) GPAT3 deficiency alleviates insulin resistance and hepatic steatosis in a mouse model of severe congenital generalized lipodystrophy. Human Molecular Genetics. 1; 29: 432-443.

Du X., Zhou L., Aw Y.C., Mak H.Y., Xu Y., Rae J., Wang W., Zadoorian A., Hancock S.E., Osborne B., Chen X., Wu J.W., Turner N., Parton R.G., Li P. and Yang H. (2020) ORP5 Localizes to ER-Lipid Droplet Contacts and Regulates the Level of PI(4)P on Lipid Droplets. Journal of Cell Biology,219, 1-16.

Qian H., Zhao X., Yan R., Gao S., Sun X., Du X., Yang H., Wong CCL. and Yan N. (2020) Structural basis for catalysis and substrate specificity of human ACAT1. NATURE, 581: 333-338.

Luo J., Yang H. and Song B.L. (2020) Nature Reviews Molecular Cell Biology.21(4): 225-245.

Wang H., Ma, Q., Qi, Y., Dong, J., Du, X., Rae, J., Brown A.J., Parton R.G., Wu J.W. and Yang H. (2019)ORP2 delivers cholesterol to the plasma membrane in exchange for phosphatidylinositol 4, 5-bisphosphate (PI(4,5)P2).Molecular Cell,73, 1–16. Cover Story.

GaoM., Huang X., SongB.L. and Yang H. (2019) Progress in Lipid Research, 75: 100989. published online July 24th.

Dong J., Du X., Wang H., Wang J., Lu C., Chen X., Zhu Z., Luo Z., Yu L., Brown A.J.,Yang H* and Wu JW*. (2019)Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2.Nature Communications, 10: 829. * co-corresponding authors.

Xu Y., Du X., Turner N., Brown AJ and Yang H. (2019) Enhanced acyl-CoA: cholesterol acyltransferase activity increases cholesterol levels on lipid droplet surface and impairs adipocyte function. Journal of Biological Chemistry, 294: 19306-19321.

Xu Y., Mak H.Y., Lukmantara I., Li Y.E., Hoehn K.L., Huang X., Du X. and Yang H. (2019) CDP-DAG Synthase 1 and 2 regulate lipid droplet growth through distinct mechanisms. Journal of Biological Chemistry, 294, 1-16;doi:10.1074/jbc.RA119.009992


Gao M. and Yang H. (2018)VPS13: A lipid transfer protein making contacts at multiple cellular locations. Journal of Cell Biology,217: 3322-3324.

Yan R., Qian H., Lukmantara I., Gao M., Du, X., Yan N. and Yang H. (2018)Human SEIPIN Binds Anionic Phospholipids.Developmental Cell, 47, 1–9.

Du X, Zadoorian A, Lukmantara I, Qi Y, Brown AJ & Yang H. (2018)Oxysterol-binding protein-related protein 5 (ORP5) promotes cell proliferation by activation of mTORC1 signaling.Journal of Biological Chemistry, 293: 3806-3818.

Du X, Turner N & Yang H. (2018)The role of oxysterol binding proteins in cancer.Seminars in Cell and Developmental Biology, 81: 149-153.

Ghai R, Du X, Wang H, Dong J, Ferguson C, Brown AJ, Parton RG, Wu JW & Yang H. (2017) ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P2) and regulate its level at the plasma membrane.Nature Communications,8:757.

Qi Y, Kapterian TS, Du X, Ma Q, Fei W, Zhang Y, Huang X, Dawes IW & Yang H. (2016).CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development.Journal of Lipid Research, 57:767-80.

Pagac M, Cooper DE, Qi Y, Lukmantara IE, Mak HY, Wu Z, Tian Y, Liu Z, Lei M, Du X, Ferguson C, Kotevski D, Sadowski P, Chen W, Boroda S, Harris TE, Liu G, Parton RG, Huang X, Coleman RA & Yang H. (2016)SEIPIN regulates lipid droplet expansion and adipocyte development through modulating the activity of glycerol-3-phosphate acyltransferase.Cell Reports, 17: 1546–1559.

Chu BB, Liao YC, Qi W, Xie C, Du X, Wang J, Yang H, Miao HH, Li BL & Song BL. (2015)Cholesterol transport through a lysosome-peroxisome membrane contact.CELL, 161: 291-306.

Du X, Brown AJ & Yang H. (2015).Novel mechanisms of intracellular cholesterol transport: membrane contact sites and oxysterol binding proteins.Current Opinion in Cell Biology, 35; 37-42.

Liu L, Jiang QQ, Wang, X, Zhang Y, Lin RC, Lan S, Shui, G, Zhou L, Li P, Wang Y, Cui X, Gao MM, Zhang L, Lv Y, Xu G, Liu G, Zhao D & Yang H. (2014)Adipose-specific knockout of seipin/BSCL2 results in progressive lipodystrophy.Diabetes,63:1–12 doi 10.2337/db13-0729

Du X, Kazim AS, Dawes IW, Brown AJ & Yang H. (2013)The AAA ATPase VPS4/SKD1 Regulates Endosomal Cholesterol Trafficking Independently of ESCRT-III.Traffic,14: 107-19.

Yang H*, Galea A, Sytnyk V & Crossley M. (2012)Controlling the size of lipid droplets: protein and lipid factors.Current Opinion in Cell Biology,24:509-16. (* corresponding author)

Cui X, Wang Y, Meng L, Fei W, Deng J, Xu G, Peng X, Ju S, Liu G, Zhao L & Yang H. (2012)Overexpression of a short isoform of human seipin/BSCL2 in mouse adipose tissue results in mild lipodystrophy.Am J Physiol Endocrinol Metab,302: E705-13.

Du X, Kazim A, Brown AJ & Yang H. (2012)An essential role of Hrs/Vps27 in endosomal cholesterol trafficking.Cell Reports, 1: 29-35. (Inaugural Issue)

Fei W, Shui G, Zhang Y, Krahmer N, Ferguson C, Kapterian TS, Lin RC, Dawes IW, Brown AJ, Li P, Huang X, Parton RG, Wenk MR, Walther TC & Yang H. (2011)
A role for phosphatidic acid in the formation of “supersized” lipid droplets.PLoS Genetics, 7: e1002201.

Cui X, Wang Y, Tang Y, Liu Y, Zhao L, Deng J, Xu G, Peng X, Ju S, Liu, G & Yang H. (2011)Seipin ablation in mice results in severe generalized lipodystrophy.Human Molecular Genetics, 20: 3022-30

Fei W, Du X & Yang H. (2011)Seipin, adipogenesis and lipid droplets.Trends in Endocrinology and Metabolism, 22: 204-10.

Du X, Kumar J, Ferguson C, Schulz TA, Ong YS, Hong W, Prinz WA, Parton RG, Brown AJ & Yang H. (2011)A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking.Journal of Cell Biology, 192: 121-135.

Fei W, Wang H, Fu X, Bielby C & Yang H. (2009)Conditions of endoplasmic reticulum stress stimulate lipid droplet formation in Saccharomyces cerevisiae.Biochemical Journal424:61-7.

Low CP, Shui GH, Liew LP, Buttner S, Madeo F, Dawes IW, Wenk MR & Yang H. (2008)Caspase-dependent and -independent lipotoxic cell-death pathways in fission yeast. Journal of Cell Science, 121: 2671-2684. Editorial highlightby JCS

Fei W, Shui G, Gaeta B, Du X, Kuerschner L, Li P, Brown AJ, Wenk MR, Parton RG & Yang H. (2008)Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast. Journal of Cell Biology,180: 473-482. Highlighted by BioCentury Science Business Xchange

Yang H. (2006)Nonvesicular sterol transport: two protein families and a sterol sensor?Trends Cell Biol. 16: 427-32. Epub 2006 Jul 28.

Wang P, Zhang Y, Li H, Chieu HK, Munn AL & Yang H. (2005)AAA ATPases regulate membrane association of yeast oxysterol binding proteins and cellular sterol metabolism.EMBO Journal,24: 2989-99

Zhang Q, Chieu HK, Low CP, Zhang S, Heng CK & Yang H. (2003)Schizosaccharomyces pombe cells deficient in triacylglycerols synthesis undergo apoptosis upon entry into the stationary phase.Journal of Biological Chemistry, 278: 47145-55

Yang H, Bard M, Bruner DA, Gleeson A, Deckelbaum RJ, Aljinovic G, Pohl T, Rothstein R & Sturley SL. (1996)Sterol Esterification in Yeast: A two gene process.Science, 272, 1353-1356.
Phone
(+61 2) 9385 8133
E-mail
H.Rob.Yang@unsw.edu.au
Location
Room: 3104, Building E26
  • Books | 2013
    , 2013, Lipid Droplets, Yang H; Li P, (ed.), ELSEVIER ACADEMIC PRESS INC,
    Books | 2013
    Yang H; Li P, 2013, Preface,
  • Book Chapters | 2021
    Yang H; Liu J, 2021, 'Structure and function of lipid droplets', in Biochemistry of Lipids, Lipoproteins and Membranes, Elsevier, pp. 357 - 394,
    Book Chapters | 2005
    Yang H, 2005, 'Metabolism of storage neutral lipids in yeast', in Daum G (ed.), Cell Biology and Dynamics of Yeast Lipids, Research Signpost, pp. 219 - 246
  • Journal articles | 2024
    Coates HW; Nguyen TB; Du X; Olzomer EM; Farrell R; Byrne FL; Yang H; Brown AJ, 2024, 'The constitutively active form of a key cholesterol synthesis enzyme is lipid droplet-localized and upregulated in endometrial cancer tissues', Journal of Biological Chemistry, 300,
    Journal articles | 2024
    Li YE; Norris DM; Xiao FN; Pandzic E; Whan RM; Fok S; Zhou M; Du G; Liu Y; Du X; Yang H, 2024, 'Phosphatidylserine regulates plasma membrane repair through tetraspanin-enriched macrodomains', Journal of Cell Biology, 223,
    Journal articles | 2024
    Liu Y; Yang H, 2024, 'WIPI4 loss linked to ferroptosis', Nature Cell Biology, 26, pp. 506 - 507,
    Journal articles | 2024
    Peng K; Chen X; Pei K; Wang X; Ma X; Liang C; Dong Q; Liu Z; Han M; Liu G; Yang H; Zheng M; Liu G; Gao M, 2024, 'Lipodystrophic gene Agpat2 deficiency aggravates hyperlipidemia and atherosclerosis in Ldlr−/− mice', Biochimica et Biophysica Acta - Molecular Basis of Disease, 1870,
    Journal articles | 2023
    Coates HW; Capell-Hattam IM; Olzomer EM; Du X; Farrell R; Yang H; Byrne FL; Brown AJ, 2023, 'Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase', eLife, 12,
    Journal articles | 2023
    Lin Y; Ran L; Du X; Yang H; Wu Y, 2023, 'Oxysterol-Binding Protein: new insights into lipid transport functions and human diseases', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1868,
    Journal articles | 2023
    Norris D; Aw Y; Yang H, 2023, 'Nonvesicular trafficking of cholesterol by Aster proteins', Life Metabolism, 2,
    Journal articles | 2023
    Tao B; Yang H; Fan R, 2023, 'Seeing the Action of Lipid Droplets in Aging and Longevity', GEN Biotechnology, 2, pp. 287 - 289,
    Journal articles | 2023
    Zadoorian A; Du X; Yang H, 2023, 'Lipid droplet biogenesis and functions in health and disease', Nature Reviews Endocrinology, 19, pp. 443 - 459,
    Journal articles | 2022
    Keable R; Hu S; Pfundstein G; Kozlova I; Su F; Du X; Yang H; Gunnersen J; Schachner M; Leshchyns’ka I; Sytnyk V, 2022, 'The BACE1-generated C-terminal fragment of the neural cell adhesion molecule 2 (NCAM2) promotes BACE1 targeting to Rab11-positive endosomes', Cellular and Molecular Life Sciences, 79,
    Journal articles | 2022
    Liang C; Wang X; Peng K; Lai P; Liu Z; Ma J; Chen X; Liu G; Zheng M; Wang Y; Yang H; Liu G; Xian X; Gao M, 2022, 'Idol Depletion Protects against Spontaneous Atherosclerosis in a Hamster Model of Familial Hypercholesterolemia', Oxidative Medicine and Cellular Longevity, 2022,
    Journal articles | 2022
    Lukmantara I; Chen F; Mak HY; Zadoorian A; Du X; Xiao FN; MacMurray Norris D; Pandzic E; Whan R; Zhong Q; Yang H, 2022, 'PI(3)P and DFCP1 regulate the biogenesis of lipid droplets', Molecular Biology of the Cell, 33,
    Journal articles | 2022
    Tang G; Ma C; Li L; Zhang S; Li F; Wu J; Yin Y; Zhu Q; Liang Y; Wang R; Huang H; Zhao TJ; Yang H; Li P; Chen FJ, 2022, 'PITPNC1 promotes the thermogenesis of brown adipose tissue under acute cold exposure', Science China Life Sciences, 65, pp. 2287 - 2300,
    Journal articles | 2022
    Xu J; Chen S; Wang W; Man Lam S; Xu Y; Zhang S; Pan H; Liang J; Huang X; Wang Y; Li T; Jiang Y; Wang Y; Ding M; Shui G; Yang H; Huang X, 2022, 'Hepatic CDP-diacylglycerol synthase 2 deficiency causes mitochondrial dysfunction and promotes rapid progression of NASH and fibrosis', Science Bulletin, 67, pp. 299 - 314,
    Journal articles | 2022
    Ye JY; Huang AJ; Fu ZZ; Gong YY; Yang HY; Zhou HW, 2022, 'A study of congenital generalized lipodystrophy (CGL) caused by BSCL2 gene mutation', Yi chuan = Hereditas, 44, pp. 926 - 936,
    Journal articles | 2021
    Chu BB; Liao YC; Qi W; Xie C; Du X; Wang J; Yang H; Miao HH; Li BL; Song BL, 2021, 'Erratum: Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts (Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts (2015) 161(2) (291–306), (S0092867415001853), (10.1016/j.cell.2015.02.019))', Cell, 184, pp. 289,
    Journal articles | 2021
    Du X; Yang H, 2021, 'Seipin regulates the formation of nuclear lipid droplets from a distance', Journal of Cell Biology, 220,
    Journal articles | 2021
    Li YE; Wang Y; Du X; Zhang T; Mak H; Hancock SE; McEwen H; Pandzic E; Whan RM; Aw YC; Lukmantara IE; Yuan Y; Dong X; Don A; Turner N; Qi S; Yang H, 2021, 'TMEM41B and VMP1 are scramblases and regulate the distribution of cholesterol and phosphatidylserine', Journal of Cell Biology, 220,
    Journal articles | 2021
    Mak HY; Ouyang Q; Tumanov S; Xu J; Rong P; Dong F; Lam SM; Wang X; Lukmantara I; Du X; Gao M; Brown AJ; Gong X; Shui G; Stocker R; Huang X; Chen S; Yang H, 2021, 'AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway', Nature Communications, 12,
    Journal articles | 2021
    Molenaar MR; Yadav KK; Toulmay A; Wassenaar TA; Mari MC; Caillon L; Chorlay A; Lukmantara IE; Haaker MW; Wubbolts RW; Houweling M; Vaandrager AB; Prieur X; Reggiori F; Choudhary V; Yang H; Schneiter R; Thiam AR; Prinz WA; Helms JB, 2021, 'Retinyl esters form lipid droplets independently of triacylglycerol and seipin', Journal of Cell Biology, 220,
    Journal articles | 2021
    Xiang J; Zhang S; Xu R; Chu H; Biswas S; Yu S; Miao D; Li W; Li S; Brown AJ; Yang H; Xu Y; Li B; Liu H, 2021, 'Elevated HB-EGF expression in neural stem cells causes middle age obesity by suppressing Hypocretin/Orexin expression', FASEB Journal, 35,
    Journal articles | 2021
    Yan R; Cao P; Song W; Qian H; Du X; Coates HW; Zhao X; Li Y; Gao S; Gong X; Liu X; Sui J; Lei J; Yang H; Brown AJ; Zhou Q; Yan C; Yan N, 2021, 'A structure of human scap bound to insig-2 suggests how their interaction is regulated by sterols', Science, 371, pp. 1012 - +,
    Journal articles | 2021
    Zhang T; Li YE; Yuan Y; Du X; Wang Y; Dong X; Yang H; Qi S, 2021, 'TMEM41B and VMP1 are phospholipid scramblases', Autophagy, 17, pp. 2048 - 2050,
    Journal articles | 2021
    Zoni V; Khaddaj R; Lukmantara I; Shinoda W; Yang H; Schneiter R; Vanni S, 2021, 'Seipin accumulates and traps diacylglycerols and triglycerides in its ring-like structure', Proceedings of the National Academy of Sciences of the United States of America, 118,
    Journal articles | 2020
    Aw YC; Brown AJ; Wu JW; Yang H, 2020, 'ORP1L, ORP1S, and ORP2: Lipid Sensors and Transporters', Contact, 3,
    Journal articles | 2020
    Dou YQ; Kong P; Li CL; Sun HX; Li WW; Yu Y; Nie L; Zhao LL; Miao SB; Li XK; Dong C; Zhang JW; Liu Y; Huo XX; Chi K; Gao X; Zhang N; Weng L; Yang H; Zhang F; Han M, 2020, 'Smooth muscle SIRT1 reprograms endothelial cells to suppress angiogenesis after ischemia', Theranostics, 10, pp. 1197 - 1212,
    Journal articles | 2020
    Du X; Yang H, 2020, 'Triacylglycerol Measurement in HeLa Cells', Bio-protocol, 10,
    Journal articles | 2020
    Du X; Zhou L; Aw YC; Mak HY; Xu Y; Rae J; Wang W; Zadoorian A; Hancock SE; Osborne B; Chen X; Wu JW; Turner N; Parton RG; Li P; Yang H, 2020, 'ORP5 localizes to ER-lipid droplet contacts and regulates the level of PI(4)P on lipid droplets', Journal of Cell Biology, 219,
    Journal articles | 2020
    Gao M; Liu L; Wang X; Mak HY; Liu G; Yang H, 2020, 'GPAT3 deficiency alleviates insulin resistance and hepatic steatosis in a mouse model of severe congenital generalized lipodystrophy', Human Molecular Genetics, 29, pp. 432 - 443,
    Journal articles | 2020
    Gao M; Yang C; Wang X; Guo M; Yang L; Gao S; Zhang X; Ruan G; Li X; Tian W; Lu G; Dong X; Ma S; Li W; Wang Y; Zhu H; He J; Yang H; Liu G; Xian X, 2020, 'ApoC2 deficiency elicits severe hypertriglyceridemia and spontaneous atherosclerosis: A rodent model rescued from neonatal death', Metabolism: Clinical and Experimental, 109,
    Journal articles | 2020
    Liu L; Liang C; Wang X; Ding X; Lu Y; Dong J; Han M; Yang H; Gao M; Liao J, 2020, 'Erratum: Author Correction: Surgical fat removal exacerbates metabolic disorders but not atherogenesis in LDLR-/- mice fed on high-fat diet (Scientific reports (2019) 9 1 (17848))', Scientific reports, 10, pp. 2181,
    Journal articles | 2020
    Luo J; Yang H; Song BL, 2020, 'Mechanisms and regulation ofcholesterol homeostasis', Nature Reviews Molecular Cell Biology, 21, pp. 225 - 245,
    Journal articles | 2020
    Qian H; Wu X; Du X; Yao X; Zhao X; Lee J; Yang H; Yan N, 2020, 'Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2', Cell
    Journal articles | 2020
    Qian H; Zhao X; Yan R; Yao X; Gao S; Sun X; Du X; Yang H; Wong CCL; Yan N, 2020, 'Structural basis for catalysis and substrate specificity of human ACAT1', Nature, 581, pp. 333 - 338
    Journal articles | 2020
    Zhao M; Zhao L; Xiong X; He Y; Huang W; Liu Z; Ji L; Pan B; Guo X; Wang L; Cheng S; Xu M; Yang H; Yin Y; Garcia-Barrio MT; Chen YE; Meng X; Zheng L, 2020, 'TMAVA, a Metabolite of Intestinal Microbes, Is Increased in Plasma From Patients With Liver Steatosis, Inhibits γ-Butyrobetaine Hydroxylase, and Exacerbates Fatty Liver in Mice', Gastroenterology, 158, pp. 2266 - 2281.e27,
    Journal articles | 2019
    Dong J; Du X; Wang H; Wang J; Lu C; Chen X; Zhu Z; Luo Z; Yu L; Brown AJ; Yang H; Wu JW, 2019, 'Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P 2 /PI(3,4)P 2', Nature Communications, 10,
    Journal articles | 2019
    Gao G; Sheng Y; Yang H; Chua BT; Xu L, 2019, 'DFCP1 associates with lipid droplets', Cell Biology International, 43, pp. 1492 - 1504,
    Journal articles | 2019
    Gao M; Huang X; Song BL; Yang H, 2019, 'The biogenesis of lipid droplets: Lipids take center stage', Progress in Lipid Research, 75,
    Journal articles | 2019
    Liu L; Liang C; Wang X; Ding X; Lu Y; Dong J; Han M; Yang H; Liao J; Gao M, 2019, 'Surgical fat removal exacerbates metabolic disorders but not atherogenesis in LDLR−/− mice fed on high-fat diet', Scientific Reports, 9,
    Journal articles | 2019
    Luo J; Jiang LY; Yang H; Song BL, 2019, 'Intracellular Cholesterol Transport by Sterol Transfer Proteins at Membrane Contact Sites', Trends in Biochemical Sciences, 44, pp. 273 - 292,
    Journal articles | 2019
    Lv X; Liu J; Qin Y; Liu Y; Jin M; Dai J; Chua BT; Yang H; Li P, 2019, 'Identification of gene products that control lipid droplet size in yeast using a high-throughput quantitative image analysis', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1864, pp. 113 - 127,
    Journal articles | 2019
    Wang H; Ma Q; Qi Y; Dong J; Du X; Rae J; Wang J; Wu WF; Brown AJ; Parton RG; Wu JW; Yang H, 2019, 'ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P 2 )', Molecular Cell, 73, pp. 458 - 473.e7,
    Journal articles | 2019
    Xu Y; Du X; Turner N; Brown AJ; Yang H, 2019, 'Enhanced acyl-CoA:cholesterol acyltransferase activity increases cholesterol levels on the lipid droplet surface and impairs adipocyte function', Journal of Biological Chemistry, 294, pp. 19306 - 19321,
    Journal articles | 2019
    Xu Y; Mak HY; Lukmantara I; Li YE; Hoehn KL; Huang X; Du X; Yang H, 2019, 'CDP-DAG synthase 1 and 2 regulate lipid droplet growth through distinct mechanisms', Journal of Biological Chemistry, 294, pp. 16740 - 16755,
    Journal articles | 2019
    Yang H, 2019, 'Extended synaptotagmins, peroxisome-endoplasmic reticulum contact and cholesterol transport', Science China Life Sciences, 62, pp. 1266 - 1269,
    Journal articles | 2018
    Du X; Turner N; Yang H, 2018, 'The role of oxysterol-binding protein and its related proteins in cancer', Seminars in Cell and Developmental Biology, 81, pp. 149 - 153,
    Journal articles | 2018
    Du X; Zadoorian A; Lukmantara IE; Qi Y; Brown AJ; Yang H, 2018, 'Oxysterol-binding protein–related protein 5 (ORP5) promotes cell proliferation by activation of MTORC1 signaling', Journal of Biological Chemistry, 293, pp. 3806 - 3818,
    Journal articles | 2018
    Gao M; Yang H, 2018, 'VPs13: A lipid transfer protein making contacts at multiple cellular locations', Journal of Cell Biology, 217, pp. 3322 - 3324,
    Journal articles | 2018
    Xu D; Li Y; Wu L; Li Y; Zhao D; Yu J; Huang T; Ferguson C; Parton RG; Yang H; Li P, 2018, 'Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions', Journal of Cell Biology, 217, pp. 975 - 995,
    Journal articles | 2017
    Bai Z; Chai XR; Yoon MJ; Kim HJ; Lo KA; Zhang ZC; Xu D; Siang DTC; Walet ACE; Xu SH; Chia SY; Chen P; Yang H; Ghosh S; Sun L, 2017, 'Dynamic transcriptome changes during adipose tissue energy expenditure reveal critical roles for long noncoding RNA regulators', PLoS Biology, 15, pp. e2002176,
    Journal articles | 2017
    Du X; Lukmantara I; Yang H, 2017, 'CRISPR/Cas9-mediated generation of niemann–pick C1 knockout cell line', , 1583, pp. 73 - 83,
    Journal articles | 2017
    Ghai R; Du X; Wang H; Dong J; Ferguson C; Brown AJ; Parton RG; Wu JW; Yang H, 2017, 'ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane', Nature Communications, 8,
    Journal articles | 2017
    Luo J; Jiang L; Yang H; Song BL, 2017, 'Routes and mechanisms of post-endosomal cholesterol trafficking: A story that never ends', Traffic, 18, pp. 209 - 217,
    Journal articles | 2017
    Qi Y; Sun L; Yang H, 2017, 'Lipid droplet growth and adipocyte development: mechanistically distinct processes connected by phospholipids', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1862, pp. 1273 - 1283,
    Journal articles | 2017
    Reid DW; Xu D; Chen P; Yang H; Sun L, 2017, 'Integrative analyses of translatome and transcriptome reveal important translational controls in brown and white adipose regulated by microRNAs', Scientific Reports, 7, pp. 5681,
    Journal articles | 2016
    Liu X; Xie B; Qi Y; Du X; Wang S; Zhang Y; Paxinos G; Yang H; Liang H, 2016, 'The expression of SEIPIN in the mouse central nervous system', Brain Structure and Function, 221, pp. 4111 - 4127,
    Journal articles | 2016
    Pagac M; Cooper DE; Qi Y; Lukmantara IE; Mak HY; Wu Z; Tian Y; Liu Z; Lei M; Du X; Ferguson C; Kotevski D; Sadowski P; Chen W; Boroda S; Harris TE; Liu G; Parton RG; Huang X; Coleman RA; Yang H, 2016, 'SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase', Cell Reports, 17, pp. 1546 - 1559,
    Journal articles | 2016
    Qi Y; Kapterian TS; Du X; Ma Q; Fei W; Zhang Y; Huang X; Dawes IW; Yang H, 2016, 'CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development', Journal of Lipid Research, 57, pp. 767 - 780,
    Journal articles | 2016
    Wang M; Gao M; Liao J; Qi Y; Du X; Wang Y; Li L; Liu G; Yang H, 2016, 'Adipose tissue deficiency results in severe hyperlipidemia and atherosclerosis in the low-density lipoprotein receptor knockout mice', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1861, pp. 410 - 418,
    Journal articles | 2015
    Chu B-B; Liao Y-C; Qi W; Xie C; Du X; Wang J; Yang H; Miao H-H; Li B-L; Song B-L, 2015, 'Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts', Cell, 161, pp. 291 - 306,
    Journal articles | 2015
    Du X; Brown AJ; Yang H, 2015, 'Novel mechanisms of intracellular cholesterol transport: oxysterol-binding proteins and membrane contact sites', Current Opinion in Cell Biology, 35, pp. 37 - 42,
    Journal articles | 2015
    Du X; Zhang Y; Jo SR; Liu X; Qi Y; Osborne B; Byrne FL; Smith GC; Turner N; Hoehn KL; Brown AJ; Yang H, 2015, 'Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1', Biochemical Journal, 471, pp. 243 - 253,
    Journal articles | 2015
    He X; Leow KY; Yang H; Heng CK, 2015, 'Functional characterization of two single nucleotide polymorphisms of acyl-coenzyme A: Cholesterol acyltransferase 2', Gene, 566, pp. 236 - 241,
    Journal articles | 2015
    Zhou L; Park SY; Xu L; Xia X; Ye J; Su L; Jeong KH; Hur JH; Oh H; Tamori Y; Zingaretti CM; Cinti S; Argente J; Yu M; Wu L; Ju S; Guan F; Yang H; Choi CS; Savage DB; Li P, 2015, 'Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27-deficient mice', Nature Communications, 6,
    Journal articles | 2014
    Jiang M; Gao M; Wu C; He H; Guo X; Zhou Z; Yang H; Xiao X; Liu G; Sha J, 2014, 'Lack of testicular seipin causes teratozoospermia syndrome in men', Proceedings of the National Academy of Sciences of the United States of America, 111, pp. 7054 - 7059,
    Journal articles | 2014
    Liu L; Jiang Q; Wang X; Zhang Y; Lin RCY; Lam SM; Shui G; Zhou L; Li P; Wang Y; Cui X; Gao M; Zhang L; Lv Y; Xu G; Liu G; Zhao D; Yang H, 2014, 'Adipose-specific knockout of Seipin/Bscl2 results in progressive lipodystrophy', Diabetes, 63, pp. 2320 - 2331,
    Journal articles | 2014
    Sun Z; Gong J; Wu H; Xu W; Wu L; Xu D; Gao J; Wu JW; Yang H; Yang M; Li P, 2014, 'Erratum: Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes (Nature Communications (2013) 4 (1594) 10.1038/ncomms2581))', Nature Communications, 5,
    Journal articles | 2014
    Wu L; Xu D; Zhou L; Xie B; Yu L; Yang H; Huang L; Ye J; Deng H; Yuan YA; Chen S; Li P, 2014, 'Rab8a-AS160-MSS4 regulatory circuit controls lipid droplet fusion and growth', Developmental Cell, 30, pp. 378 - 393,
    Journal articles | 2013
    Aung-Htut MT; Lam YT; Lim YL; Rinnerthaler M; Gelling CL; Breitenbach M; Yang H; Dawes IW, 2013, 'Maintenance of mitochondrial morphology by autophagy and its role in high glucose effects on chronological lifespan of Saccharomyces cerevisiae', Oxidative Medicine and Cellular Longevity, 2013, pp. 1 - 13,
    Journal articles | 2013
    Du X; Kazim AS; Dawes IW; Brown AJ; Yang H, 2013, 'The AAA ATPase VPS4/SKD1 regulates endosomal cholesterol trafficking independently of ESCRT-III.', Traffic, 14, pp. 107 - 119,
    Journal articles | 2013
    Du X; Yang H, 2013, 'Endosomal cholesterol trafficking: protein factors at a glance.', ACTA Biochimica et Biophysica Sinica, 45, pp. 11 - 17,
    Journal articles | 2013
    Lu Y; Tayebi N; Li H; Saha N; Yang H; Heng CK, 2013, 'Association of CETP Taq1B and -629C > A polymorphisms with coronary artery disease and lipid levels in the multi-ethnic Singaporean population', Lipids in Health and Disease, 12,
    Journal articles | 2013
    Tong J; Yang H; Yang H; Eom SH; Im YJ, 2013, 'Structure of Osh3 reveals a conserved mode of phosphoinositide binding in oxysterol-binding proteins', Structure, 21, pp. 1203 - 1213,
    Journal articles | 2013
    Yang H; Li P; Gong J; Sun Z, 2013, 'Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes.', Nature communications, 4, pp. 1594,
    Journal articles | 2012
    Cui X; Wang Y; Meng L; Fei W; Deng J; Xu G; Peng X; Ju SH; Zhang L; Liu G; Zhao L; Yang H, 2012, 'Overexpression of a short human seipin/bscl2 isoform in mouse adipose tissue results in mild lipodystrophy', American Journal of Physiology - Endocrinology and Metabolism, 302, pp. 705 - 713
    Journal articles | 2012
    Du X; Kazim A; Brown AJ; Yang H, 2012, 'An essential role of Hrs/Vps27 in endosomal cholesterol trafficking', Cell Reports, 1, pp. 29 - 35
    Journal articles | 2012
    Ta MT; Kapterian T; Fei W; Du X; Brown AJ; Dawes IW; Yang H, 2012, 'Accumulation of squalene is associated with the clustering of lipid droplets.', FEBS Journal, 279, pp. 4231 - 4244,
    Journal articles | 2012
    Tian N; Leshchyns'ka I; Welch J; Diakowski W; Yang H; Schachner M; Sytnyk V, 2012, 'Lipid raft-dependent endocytosis of close homolog of adhesion molecule L1 (CHL1) promotes neuritogenesis.', The Journal of Biological Chemistry, 287, pp. 44447 - 44463,
    Journal articles | 2012
    Yang H; Fei W, 2012, 'Genome-wide screens for gene products regulating lipid droplet dynamics', Methods in Cell Biology, 108, pp. 303 - 316,
    Journal articles | 2012
    Yang H; Liu P; Ding Y, 2012, 'Identification of the major functional proteins of prokaryotic lipid droplets', Journal of Lipid Research, 53, pp. 399 - 411,
    Journal articles | 2012
    Yang H; Sytnyk V; Crossley M; Galea AM, 2012, 'Controlling the size of lipid droplets: Lipid and protein factors', Current Opinion in Cell Biology, 24, pp. 509 - 516,
    Journal articles | 2011
    Cui X; Wang Y; Tang Y; Liu G; Yang H; Liu Y; Zhao L; Deng J; Xu G; Peng X; Ju SH, 2011, 'Seipin ablation in mice results in severe generalized lipodystrophy', Human Molecular Genetics, 20, pp. 3022 - 3030,
    Journal articles | 2011
    Du X; Yang H, 2011, 'Sterol-binding proteins and endosomal cholesterol transport', Frontiers in Biology, 6, pp. 190 - 196
    Journal articles | 2011
    Du XR; Kumar J; Ferguson C; Schulz TA; Ong YS; Hong W; Prinz WA; Parton RG; Brown AJ; Yang H, 2011, 'A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking', Journal of Cell Biology, 192, pp. 121 - 135,
    Journal articles | 2011
    Fei W; Du XR; Yang H, 2011, 'Seipin, adipogenesis and lipid droplets.', Trends in Endocrinology and Metabolism, 22, pp. 204 - 210,
    Journal articles | 2011
    Fei W; Li H; Shui G; Kapterian TS; Bielby C; Du X; Brown AJ; Li P; Wenk M; Liu P; Yang H, 2011, 'Molecular characterization of seipin and its mutants: implications for seipin in triacylglycerol synthesis.', Journal of Lipid Research, 52, pp. 2136 - 2147,
    Journal articles | 2011
    Fei W; Shui G; Zhang Y; Krahmer N; Ferguson C; Kapterian T; Lin RCY; Dawes IW; Brown AJ; Li P; Huang X; Parton R; Wenk M; Walther TC; Yang H, 2011, 'A role for phosphatidic acid in the formation of “supersized” lipid droplets', PLOS Genetics, 7, pp. e1002201 1 - e1002201 11,
    Journal articles | 2011
    Fei W; Zhong L; Ta T; Yang H, 2011, 'The size and phospholipid composition of lipid droplets can influence their proteome', Biochemical and Biophysical Research Communications, 415, pp. 455 - 462,
    Journal articles | 2011
    Lam YT; Aung MT; Lim YL; Yang H; Dawes IW, 2011, 'Changes in reactive oxygen species begin early during replicative aging of Saccharomyces cerevisiae cells', Free Radical Biology and Medicine, 50, pp. 963 - 970,
    Journal articles | 2011
    Yang H; Parton RG; Li P; Shui G; Gong J, 2011, 'Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites', Journal of Cell Biology, 195, pp. 953 - 963,
    Journal articles | 2011
    tian Y; Bi J; Shui G; Wenk M; Yang H; Huang X, 2011, 'Tissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formation', PLOS Genetics, 7, pp. e1001364,
    Journal articles | 2010
    Shui G; Guan XL; Gopalakrishnan P; Xue Y; Goh JSY; Yang H; Wenk MR, 2010, 'Characterization of substrate preference for Slc1p and Cst26p in Saccharomyces cerevisiae using lipidomic approaches and an LPAAT activity assay', PLoS One, 4, pp. 11956,
    Journal articles | 2010
    Shui G; Guan XL; Gopalakrishnan P; Xue Y; Goh JSY; Yang H; Wenk MR, 2010, 'Characterization of substrate preference for Slc1p and Cst26p in saccharomyces cerevisiae using lipidomic approaches and an LPAAT activity assay', PLoS ONE, 5,
    Journal articles | 2010
    Yang H, 2010, 'Toward one step analysis of cellular lipidomes using liquid', Molecular Biosystems, 6, pp. 1008 - 1017,
    Journal articles | 2009
    Fei W; Wang H; Fu X; Christopher B; Yang H, 2009, 'Conditions of endoplasmic reticulum stress stimulate lipid droplet formation in saccharomyces cerevisiae', Biochemical Journal, 424, pp. 61 - 67,
    Journal articles | 2008
    Fei W; Alfaro G; Muthusamy B; Klaassen Z; Graham T; Yang H; Beh C, 2008, 'Genome-wide analysis of sterol-lipid storage and trafficking in Saccharomyces cerevisiae', Eukaryotic Cell, pp. 401 - 414
    Journal articles | 2008
    Fei W; Shui G; Gaeta BA; Du XR; Kuerschner L; Liu P; Brown AJ; Wenk M; Parton R; Yang H, 2008, 'Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast', Journal of Cell Biology, 180, pp. 473 - 482,
    Journal articles | 2008
    Kristiana I; Yang H; Brown AJ, 2008, 'Different kinetics of cholesterol delivery to components of the cholesterol homeostatic machinery: Implications for cholesterol trafficking to the endoplasmic reticulum', Biochimica et Biophysica ACTA - Molecular and Cell Biology of Lipids, 1781, pp. 724 - 730
    Journal articles | 2008
    Low C; Shui G; Liew L; Buttner S; Madeo F; Dawes IW; Wenk M; Yang H, 2008, 'Caspase-dependent and -independent lipotoxic cell-death pathways in fission yeast', Journal of Cell Science, 121, pp. 2671 - 2684,
    Journal articles | 2008
    Low C; Yang H, 2008, 'Programmed cell death in fission yeast Schizosaccharomyces pombe', Biochimica et Biophysica ACTA - Molecular Cell Research, 1783, pp. 1335 - 1349
    Journal articles | 2008
    Toh SK; Gong J; Du GG; Li J; Yang S; Ye JM; Yao H; Zhang Y; Xue B; Li Q; Yang H; Wen Z; Li P, 2008, 'Up-regulation of mitochondrial activity and acquirement of brown adipose tissue-like property in the white adipose tissue of Fsp27 deficient mice', PLoS One, 3, pp. 2890 - 2891
    Journal articles | 2006
    Chen X; Hu ZP; Yang XX; Huang M; Gao Y; Tang W; Chan SY; Dai X; Ye J; Ho PCL; Duan W; Yang HY; Zhu YZ; Zhou SF, 2006, 'Monitoring of immune responses to a herbal immuno-modulator in patients with advanced colorectal cancer', International Immunopharmacology, 6, pp. 499 - 508,
    Journal articles | 2006
    Tian Q; Zhang J; Chan SY; Tan T; Duan W; Huang M; Zhu Y; Chan E; Yu Q; Nie YQ; Ho P; Li Q; Ng K; Yang H; Wei HE; Bian JS; Zhou S, 2006, 'Topotecan is a substrate for multidrug resistance associated protein 4', Current Drug Metabolism, 7, pp. 105 - 118
    Journal articles | 2006
    Yang H, 2006, 'Nonvesicular sterol transport: two protein families and a sterol sensor?', Trends in Cell Biology, 16, pp. 427 - 432
    Journal articles | 2006
    Zhang J; Huang M; Guan S; Bi HC; Pan Y; Duan W; Chan SY; Chen X; Hong YH; Bian JS; Yang H; Zhou S, 2006, 'A mechanistic study of the intestinal absorption of Cryptotanshinone, the major active constituent of Salvia miltiorrhiza', Journal of Pharmacology and Experimental Therapeutics, 317, pp. 1285 - 1294
    Journal articles | 2005
    Gao Y; Gao H; Chan E; Tang W; Xu A; Yang H; Huang M; Lan J; Li X; Duan W; Xu C; Zhou S, 2005, 'Antitumor activity and underlying mechanisms of ganopoly, the refined polysaccharides extracted from ganoderma lucidum, in mice', Immunological Investigations, 34, pp. 171 - 198,
    Journal articles | 2005
    He X; Lu Y; Saha N; Yang H; Heng CK, 2005, 'Acyl-CoA: Cholesterol acyltransferase-2 gene polymorphisms and their association with plasma lipids and coronary artery disease risks', Human Genetics, 118, pp. 393 - 403
    Journal articles | 2005
    Hu Z; Yang XQ; Ho P; Chan E; Chan S; Xu C; Li XR; Zhu YZ; Duan W; Chen X; Huang M; Yang H; Zhou S, 2005, 'St John`s Wort modulates the toxicities and pharmacokinetics of CPT-11 (irinotecan) in rats', Pharmaceutical Research, 22, pp. 902 - 914
    Journal articles | 2005
    Lim G; Zhu Y; Wang C; Tan B; Armstrong J; Dokland T; Yang H; Zhu YZ, 2005, 'The last five amino acid residues at the C-terminus of PRK1/PKN are essential for full lipid responsiveness', Cellular Signalling, 17, pp. 1084 - 1097
    Journal articles | 2005
    Low C; Liew L; Pervaiz S; Yang H, 2005, 'Apoptosis and lipoapoptosis in yeast', Human Genetics, 5, pp. 1199 - 1206
    Journal articles | 2005
    Low CP; Liew LP; Pervaiz S; Yang H, 2005, 'Apoptosis and lipoapoptosis in the fission yeast Schizosaccharomyces pombe', FEMS Yeast Research, 5, pp. 1199 - 1206,
    Journal articles | 2005
    Tian Q; Zhang J; Tan T; Chan E; Duan W; Chan S; Boelsterli UA; Ho P; Yang H; Bian JS; Huang M; Zhu Y; Xiong W; Li XR; Zhou S, 2005, 'Human multidrug resistance associated protein 4 confers resistance to camptothecins', Pharmaceutical Research, 22, pp. 1837 - 1853
    Journal articles | 2005
    Tian Q; Zhang J; Tan TMC; Chan E; Duan W; Chan SY; Boelsterli UA; Ho PC-L; Yang H; Bian J-S; Huang M; Zhu Y-Z; Xiong W; Li X; Zhou S, 2005, 'Human multidrug resistance associated protein 4 confers resistance to camptothecins.', Pharm Res, 22, pp. 1837 - 1853,
    Journal articles | 2005
    Wang P; Duan W; Munn AL; Yang H, 2005, 'Molecular characterization of Oshop, an oxysterol binding protein homolog in the yeast Saccharomyces cerevisiae', FEBS Journal, 272, pp. 4703 - 4715
    Journal articles | 2005
    Wang P; Zhang Y; Li H; Chieu HK; Munn AL; Yang H, 2005, 'AAA ATPases regulate membrane association of yeast oxysterol binding proteins and cellular sterol metabolism', European Molecular Biology Organization, 24, pp. 2989 - 2999
    Journal articles | 2005
    Wang Q; Ting WL; Yang H; Wong PT, 2005, 'High doses of simavastatin upregulate dopamine D(1) and D(2) receptor expression in the rat prefrontal cortex: possible involvement of endothelial nitric oxide synthase', British Journal of Pharmacology, 144, pp. 933 - 939
    Journal articles | 2005
    Zhou S; Huang M; Xu A; Yang H; Duan W; Paxton JW, 2005, 'Prediction of herb-drug metabolic interactions: A simulation study', Phytotherapy Research, 19, pp. 464 - 471,
    Journal articles | 2004
    Armstrong J; Whiteman M; Yang H; Jones DP, 2004, 'The redox regulation of intermediary metabolism by a superoxide-acontase rheostat', BioEssays, 26, pp. 894 - 900
    Journal articles | 2004
    Armstrong J; Yang H; Duan W; Whiteman M, 2004, 'Cytochrome bc1 regulates the mitochondrial permeability transition by two distinct pathways', The Journal of Biological Chemistry, 279, pp. 50420 - 50428
    Journal articles | 2004
    Armstrong JS; Whiteman M; Yang H; Jones DP; Sternberg P, 2004, 'Cysteine starvation activates the redox-dependent mitochondrial permeability transition in retinal pigment epithelial cells', Investigative Ophthalmology and Visual Science, 45, pp. 4183 - 4189,
    Journal articles | 2004
    Kim K; Shin YK; Park J; Kim JH; Yang H; Han DM; Paik Y, 2004, 'Molecular cloning and biochemical characterization of Candida albicans acyl-CoA:sterol acyltransferase, a potential target of antifungal agents', Biochemical and Biophysical Research Communications, 2319, pp. 911 - 919
    Journal articles | 2004
    Zhang SP; Ren J; Zhang Q; Armstrong J; Munn AL; Yang H, 2004, 'Cysteine starvation activates the redox-dependent mitochondrial permeability transition in retinal pigment epithelial cells', Traffic (Malden), 5, pp. 1017 - 1030
    Journal articles | 2004
    Zhang SP; Ren J; Zhang Q; Munn AL; Armstrong J; Yang H, 2004, 'Ncr1p, the yeast ortholog of mammalian Niemann Pick C1 protein, is dispensable for endocytic transport.', Traffic (Malden), 5, pp. 1017 - 1030
    Journal articles | 2003
    Tan JH; Low PS; Tan YS; Tong MC; Saha N; Yang H; Heng CK, 2003, 'ABCA1 gene polymorphisms and their associations with coronary artery disease and plasma lipids in males from three ethnic populations in Singapore', Human Genetics, 113, pp. 106 - 117
    Journal articles | 2003
    Woo WH; Yang H; Wong KP; Halliwell B, 2003, 'Sulphite oxidase gene expression in human brain and in other human and rat tissues', Biochemical and Biophysical Research Communications, 305, pp. 619 - 623
    Journal articles | 2003
    Yeo SC; Xu LL; Ren J; Boulton VJ; Wagle MD; Liu CF; Ren G; Wong P; Zahn DR; Sasajala P; Yang H; Piper RD; Munn AL, 2003, 'Vps20p and Vta1p interact with Vps4p and function in multivesicular body sorting and endosomal transport in Saccharomyces cerevisiae', Journal of Cell Science, 116, pp. 3957 - 3970
    Journal articles | 2003
    Zhang Q; Chieu HK; Low C; Zhang SP; Heng CK; Yang H, 2003, 'Schizosaccharomyces pombe cells deficient in Triacylglycerols synthesis undergo apoptosis upon entry into the stationary phase', The Journal of Biological Chemistry, 278, pp. 47145 - 47155
    Journal articles | 2001
    Li T; Duan W; Yang H; Lee MK; Bte Mustafa F; Lee BH; Teo TS, 2001, 'Identification of two proteins, S14 and UIP1, that interact with UCH37', FEBS Letters, 488, pp. 201 - 205,
    Journal articles | 2000
    Li T; Naqvi NI; Yang H; Teo TS, 2000, 'Identification of a 26S proteasome-associated UCH in fission yeast', Biochemical and Biophysical Research Communications, 272, pp. 270 - 275,
    Journal articles | 1998
    Liang JS; Wu X; Jiang H; Zhou M; Yang H; Angkeow P; Huang LS; Sturley SL; Ginsberg H, 1998, 'Translocation efficiency, susceptibility to proteasomal degradation, and lipid responsiveness of apolipoprotein B are determined by the presence of β sheet domains', Journal of Biological Chemistry, 273, pp. 35216 - 35221,
    Journal articles | 1997
    Yang H; Cromley D; Wang H; Billheimer JT; Sturley SL, 1997, 'Functional expression of a cDNA to human acyl-coenzyme A:cholesterol acyltransferase in yeast. Species-dependent substrate specificity and inhibitor sensitivity', Journal of Biological Chemistry, 272, pp. 3980 - 3985,
    Journal articles | 1996
    Arthington-Skaggs BA; Crowell DN; Yang H; Sturley SL; Bard M, 1996, 'Positive and negative regulation of a sterol biosynthetic gene (ERG3) in the post-squalene portion of the yeast ergosterol pathway', FEBS Letters, 392, pp. 161 - 165,
    Journal articles | 1996
    Yang H; Bard M; Bruner DA; Gleeson A; Deckelbaum RJ; Aljinovic G; Pohl TM; Rothstein R; Sturley SL, 1996, 'Sterol esterification in yeast: A two-gene process', Science, 272, pp. 1353 - 1356,
    Journal articles | 1995
    Piper RC; Cooper AA; Yang H; Stevens TH, 1995, 'VPS27 controls vacuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae', Journal of Cell Biology, 131, pp. 603 - 617,
    Journal articles |
    Yan R; Qian H; Lukmantara I; Gao M; Du X; Yan N; Yang H, 'Human SEIPIN Binds Anionic Phospholipids', Dev. Cell, 47, pp. 248 - 256
  • Preprints | 2024
    Wu J; Gao M; Wu X; Liu Y; Du X; Liang Y; Ma C; Li P; Chen F-J; Yang H, 2024, PI(4)P recruits CIDE proteins to promote the formation of unilocular lipid droplets during adipogenesis and hepatic steatosis,
    Preprints | 2022
    Amanda Tan RP; Kozlova I; Su F; Sah S; Keable R; Hagan W; Bustamante S; Du X; Osborne B; Turner N; Clemens K; Begg D; Phelps E; Yang H; Leshchyns’ka I; Sytnyk V, 2022, Neuronal growth regulator 1 (NEGR1) promotes synaptic targeting of glutamic acid decarboxylase 65 (GAD65),
    Preprints | 2022
    Coates H; Olzomer E; Du X; Farrell R; Yang H; Byrne F; Brown A, 2022, Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase, ,

My Research Supervision

In 2021, there will be twoPh.D. students and three honors students